Product documentation
Ask about batch-specific certificates of analysis, test methods and available documentation for PT-141. Confirm that any report matches the lot you intend to order — what a certificate of analysis reports covers which field answers which question.
Request documentation for PT-141PT-141
PT-141 10mg - bremelanotide, a melanocortin receptor agonist studied for central nervous system signaling rather than vascular pathways.
Research Use Only:This compound is intended exclusively for in vitro laboratory research applications. Not for human or veterinary consumption.
PT-141 research overview
PT-141, also called bremelanotide, is a cyclic heptapeptide analogue of alpha-melanocyte stimulating hormone. It is a metabolite of melanotan II, differing by the replacement of a C-terminal amide with a hydroxyl group, and that single change substantially alters its receptor selectivity profile.
Its research interest lies in where it acts. PT-141 is studied as an agonist at melanocortin receptors MC3R and MC4R, both expressed in the central nervous system, and the literature examines signaling within the hypothalamus and downstream neural pathways. That places it in a different category from PDE5 inhibitors such as tadalafil, which act on vascular smooth muscle through cyclic GMP. Models comparing central and peripheral mechanisms often run the two side by side for exactly that reason. Published work also examines MC4R involvement in appetite regulation and energy balance, which is a separate strand of melanocortin research.
Savage Labs stocks PT-141 as a 10mg lyophilized vial, alongside MT-2, its structural parent, which retains stronger MC1R activity and therefore a different research profile. Store the sealed vial refrigerated at 2-8 degrees Celsius, protected from light. For in vitro laboratory research only. Not for human or veterinary use.
- MC3R and MC4R receptor agonist research
- Central versus peripheral mechanism comparison
- Hypothalamic signaling studies
- Appetite and energy balance investigations
- Melanocortin structure-activity work against MT-2
PT-141 specifications
| Form | Lyophilized Powder |
|---|---|
| Storage | Refrigerate at 2-8°C, protect from light |
| Quantity | 10mg / vial |
| Research Use | In vitro laboratory research only |
| Reported Purity | 99% |
| Receptor Targets | MC3R and MC4R |
Questions about this listing
- What form does PT-141 come in?
Lyophilized Powder The size options listed on this page — 10mg — are what is available, and the vial labelling shown in the product images above is the reference for what a vial contains.
- How should PT-141 be stored?
Refrigerate at 2-8°C, protect from light. Storage requirements differ across the catalog — some listings are refrigerated, others held at -20°C, others at room temperature — so read this row rather than assuming from a neighbouring product.
- Does Savage Labs supply a diluent for PT-141?
Bacteriostatic water is stocked separately in 3mL and 10mL vials. Savage Labs does not specify a reconstitution volume, a working concentration, or a basis for calculating either — those are determined by the protocol the material is used in, not by this catalog.
- What does the 99% figure on this listing mean?
It is the purity reported for this material. It is a reported value rather than one Savage Labs has independently verified for the lot you receive, and it does not describe net peptide content. How peptide purity is reported and net peptide content cover what the number does and does not tell you.
- What documentation is available for PT-141?
Batch-specific certificates of analysis and test methods on request. Confirm that any report matches the lot you intend to order — reading a peptide certificate of analysis covers which field answers which question. Ask about documentation for this listing, or see the full FAQ for ordering, shipping and returns.
- What else is grouped with PT-141?
It is catalogued under Sexual Health, where the category page describes what separates the compounds in the group.
Ordering, payment, shipping and returns are answered on the full FAQ.
References
The published work the description above draws on. These are indexed records, not Savage Labs documentation, and none of them establishes a use for PT-141 in people or animals. For records covering the material itself, ask about batch documentation.
- Structural insights into ligand recognition and activation of the melanocortin-4 receptor — Cell Res (2021) · PMID 34433901
- Novel approaches to the design of bioavailable melanotropins — Expert Opin Drug Discov (2017) · PMID 28699792
