Product documentation
Ask about batch-specific certificates of analysis, test methods and available documentation for KPV. Confirm that any report matches the lot you intend to order — what a certificate of analysis reports covers which field answers which question.
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KPV 10mg - the C-terminal tripeptide of alpha-MSH, studied for anti-inflammatory signaling without melanocortin receptor pigmentation activity.
Research Use Only:This compound is intended exclusively for in vitro laboratory research applications. Not for human or veterinary consumption.
KPV research overview
KPV is a tripeptide of lysine, proline and valine corresponding to the C-terminal fragment of alpha-melanocyte stimulating hormone. Its research interest comes from an unusual property for a fragment: it retains a substantial part of the anti-inflammatory activity attributed to the full alpha-MSH molecule while lacking the pigmentation activity that the intact peptide carries through MC1R.
That separation is what makes KPV useful as a laboratory tool. Published work has examined its effect on NF-kappaB and MAPK signaling, its transport into intestinal epithelial and immune cells via the PepT1 transporter, and its behaviour in colitis and mucosal inflammation models. Because it appears to act intracellularly rather than solely at the cell surface, it is often included in study designs that need to distinguish receptor-mediated from intracellular anti-inflammatory effects.
Savage Labs stocks KPV as a 10mg lyophilized vial and also as a component of the KLOW blend, where it sits alongside GHK-Cu, BPC-157 and TB-4. If a protocol needs to attribute an observed effect to KPV specifically, the single-compound vial is the correct starting point. Store refrigerated at 2-8 degrees Celsius, protected from light, and reconstitute immediately before use. For in vitro laboratory research only. Not for human or veterinary use.
- NF-kappaB and MAPK signaling research
- Intestinal and mucosal inflammation models
- PepT1 transporter uptake studies
- Alpha-MSH fragment structure-activity work
- Anti-inflammatory assays without pigmentation confound
KPV specifications
| Form | Lyophilized Powder |
|---|---|
| Storage | Refrigerate at 2-8°C, protect from light |
| Quantity | 10mg / vial |
| Composition | Lys-Pro-Val tripeptide |
| Research Use | In vitro laboratory research only |
| Reported Purity | 99% |
Questions about this listing
- What form does KPV come in?
Lyophilized Powder The size options listed on this page — 10mg — are what is available, and the vial labelling shown in the product images above is the reference for what a vial contains.
- How should KPV be stored?
Refrigerate at 2-8°C, protect from light. Storage requirements differ across the catalog — some listings are refrigerated, others held at -20°C, others at room temperature — so read this row rather than assuming from a neighbouring product.
- Does Savage Labs supply a diluent for KPV?
Bacteriostatic water is stocked separately in 3mL and 10mL vials. Savage Labs does not specify a reconstitution volume, a working concentration, or a basis for calculating either — those are determined by the protocol the material is used in, not by this catalog.
- What does the 99% figure on this listing mean?
It is the purity reported for this material. It is a reported value rather than one Savage Labs has independently verified for the lot you receive, and it does not describe net peptide content. How peptide purity is reported and net peptide content cover what the number does and does not tell you.
- What documentation is available for KPV?
Batch-specific certificates of analysis and test methods on request. Confirm that any report matches the lot you intend to order — reading a peptide certificate of analysis covers which field answers which question. Ask about documentation for this listing, or see the full FAQ for ordering, shipping and returns.
- What else is grouped with KPV?
It is catalogued under Healing & Recovery, where the category page describes what separates the compounds in the group.
Ordering, payment, shipping and returns are answered on the full FAQ.
References
The published work the description above draws on. These are indexed records, not Savage Labs documentation, and none of them establishes a use for KPV in people or animals. For records covering the material itself, ask about batch documentation.
- PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation — Gastroenterology (2008) · PMID 18061177
- Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis — Mol Ther (2017) · PMID 28143741
