Product documentation
Ask about batch-specific certificates of analysis, test methods and available documentation for MOTS-c. Confirm that any report matches the lot you intend to order — what a certificate of analysis reports covers which field answers which question.
Request documentation for MOTS-cMOTS-c
MOTS-c 10mg - a mitochondrial-derived peptide encoded in the 12S rRNA reading frame, studied for AMPK signaling and metabolic research.
Research Use Only:This compound is intended exclusively for in vitro laboratory research applications. Not for human or veterinary consumption.
MOTS-c research overview
MOTS-c is a short peptide whose coding sequence sits inside the mitochondrial 12S ribosomal RNA gene rather than in nuclear DNA. That origin is the reason it attracted attention: it demonstrated that the mitochondrial genome encodes signaling peptides acting outside the organelle, not only components of the respiratory chain.
Research has concentrated on AMPK activation and on the folate-methionine cycle, through which MOTS-c is reported to affect purine biosynthesis and thereby cellular energy sensing. Published work has examined glucose uptake in skeletal muscle preparations, insulin sensitivity in metabolic models, and translocation of the peptide to the nucleus under metabolic stress, where it appears to influence stress-response gene expression. It is frequently described in the literature as an exercise-associated peptide because circulating levels change with physical activity in the models studied.
Savage Labs supplies MOTS-c as a 10mg lyophilized vial. It sits in the metabolic group alongside the incretin receptor agonists but reaches metabolic endpoints through an entirely different mechanism, which makes it useful as a mechanistic contrast rather than as an alternative to them. Store at -20 degrees Celsius and avoid repeated freeze-thaw cycles. For in vitro laboratory research only. Not for human or veterinary use.
- AMPK activation and energy sensing research
- Folate-methionine cycle studies
- Skeletal muscle glucose uptake models
- Nuclear translocation and stress-response gene work
- Mitochondrial-derived peptide investigations
MOTS-c specifications
| Form | Lyophilized Powder |
|---|---|
| Origin | Mitochondrial 12S rRNA open reading frame |
| Storage | Store at -20°C, avoid freeze-thaw |
| Quantity | 10mg / vial |
| Research Use | In vitro laboratory research only |
| Reported Purity | 99% |
Questions about this listing
- What form does MOTS-c come in?
Lyophilized Powder The size options listed on this page — 10mg — are what is available, and the vial labelling shown in the product images above is the reference for what a vial contains.
- How should MOTS-c be stored?
Store at -20°C, avoid freeze-thaw. Storage requirements differ across the catalog — some listings are refrigerated, others held at -20°C, others at room temperature — so read this row rather than assuming from a neighbouring product.
- Does Savage Labs supply a diluent for MOTS-c?
Bacteriostatic water is stocked separately in 3mL and 10mL vials. Savage Labs does not specify a reconstitution volume, a working concentration, or a basis for calculating either — those are determined by the protocol the material is used in, not by this catalog.
- What does the 99% figure on this listing mean?
It is the purity reported for this material. It is a reported value rather than one Savage Labs has independently verified for the lot you receive, and it does not describe net peptide content. How peptide purity is reported and net peptide content cover what the number does and does not tell you.
- What documentation is available for MOTS-c?
Batch-specific certificates of analysis and test methods on request. Confirm that any report matches the lot you intend to order — reading a peptide certificate of analysis covers which field answers which question. Ask about documentation for this listing, or see the full FAQ for ordering, shipping and returns.
- What else is grouped with MOTS-c?
It is catalogued under Metabolic, where the category page describes what separates the compounds in the group.
Ordering, payment, shipping and returns are answered on the full FAQ.
References
The published work the description above draws on. These are indexed records, not Savage Labs documentation, and none of them establishes a use for MOTS-c in people or animals. For records covering the material itself, ask about batch documentation.
- The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance — Cell Metab (2015) · PMID 25738459
- The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress — Cell Metab (2018) · PMID 29983246
