Product documentation
Ask about batch-specific certificates of analysis, test methods and available documentation for IGF-LR3. Confirm that any report matches the lot you intend to order — what a certificate of analysis reports covers which field answers which question.
Request documentation for IGF-LR3IGF-LR3
IGF-1 LR3 1mg - a long arginine-3 IGF-1 analogue with reduced binding protein affinity, studied for receptor signaling research.
Research Use Only:This compound is intended exclusively for in vitro laboratory research applications. Not for human or veterinary consumption.
IGF-LR3 research overview
IGF-1 LR3 is an analogue of insulin-like growth factor 1 carrying two changes: an arginine substitution at position 3 and a 13-amino-acid extension at the N-terminus. Both exist to weaken the peptide's affinity for the IGF binding proteins that normally sequester circulating IGF-1.
That matters because in a standard preparation the great majority of IGF-1 is bound to IGFBPs rather than free, and the fraction available to the receptor is a moving target that depends on binding protein concentration in the medium. Reducing binding protein affinity makes the free fraction far more predictable, which is why LR3 appears in receptor signaling work where the concentration reaching the IGF-1 receptor needs to be known rather than estimated. Published models have used it to study cell proliferation and differentiation, PI3K/Akt and MAPK pathway activation, myoblast behaviour and hypertrophy signaling.
It sits downstream of the growth hormone secretagogues Savage Labs stocks - CJC-1295 DAC, ipamorelin and tesamorelin - at the growth factor rather than the release end. The trade-off is that LR3 is not a substitute for native IGF-1 in any model where binding protein interaction is itself the subject. This listing supplies 1mg of lyophilized powder. Store at -20 degrees Celsius and avoid repeated freeze-thaw cycles. For in vitro laboratory research only. Not for human or veterinary use.
- IGF-1 receptor signaling research
- PI3K/Akt and MAPK pathway studies
- Cell proliferation and differentiation models
- Myoblast and hypertrophy signaling work
- Reduced IGFBP interference in culture
IGF-LR3 specifications
| Form | Lyophilized Powder |
|---|---|
| Storage | Store at -20°C, avoid freeze-thaw |
| Quantity | 1mg / vial |
| Modification | Arg3 substitution + 13-residue N-terminal extension |
| Research Use | In vitro laboratory research only |
| Reported Purity | 99% |
Questions about this listing
- What form does IGF-LR3 come in?
Lyophilized Powder The size options listed on this page — 1mg — are what is available, and the vial labelling shown in the product images above is the reference for what a vial contains.
- How should IGF-LR3 be stored?
Store at -20°C, avoid freeze-thaw. Storage requirements differ across the catalog — some listings are refrigerated, others held at -20°C, others at room temperature — so read this row rather than assuming from a neighbouring product.
- Does Savage Labs supply a diluent for IGF-LR3?
Bacteriostatic water is stocked separately in 3mL and 10mL vials. Savage Labs does not specify a reconstitution volume, a working concentration, or a basis for calculating either — those are determined by the protocol the material is used in, not by this catalog.
- What does the 99% figure on this listing mean?
It is the purity reported for this material. It is a reported value rather than one Savage Labs has independently verified for the lot you receive, and it does not describe net peptide content. How peptide purity is reported and net peptide content cover what the number does and does not tell you.
- What documentation is available for IGF-LR3?
Batch-specific certificates of analysis and test methods on request. Confirm that any report matches the lot you intend to order — reading a peptide certificate of analysis covers which field answers which question. Ask about documentation for this listing, or see the full FAQ for ordering, shipping and returns.
- What else is grouped with IGF-LR3?
It is catalogued under Growth Hormone, where the category page describes what separates the compounds in the group.
Ordering, payment, shipping and returns are answered on the full FAQ.
References
The published work the description above draws on. These are indexed records, not Savage Labs documentation, and none of them establishes a use for IGF-LR3 in people or animals. For records covering the material itself, ask about batch documentation.
- Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig — J Endocrinol (1995) · PMID 7561636
- Effect of IGFBP-3 on IGF- and IGF-analogue-induced insulin-like growth factor-I receptor (IGFIR) signalling — Growth Horm IGF Res (2001) · PMID 11735239
